The Cardinals open the season with two consecutive games against the NFC South.
The Arizona Cardinals will release their full 2025 regular-season schedule at 5 p.m. Arizona Cardinals, but we have some information. We know they will open the season on the road against the New Orleans Saints.
It would appear they will have their home opener the very next week.
According to Johnny Venerable of PHNX, the Cardinals will host the Carolina Panthers in Week 2 for their home opener at State Farm Stadium.
It will be the second consecutive season the Cardinals have faced the Panthers and the sixth time in the last seven years. The Cardinals lost 36-30 in overtime last season in Carolina in December, which basically knocked the Cardinals out of postseason contention. They are 1-4 in the last five regular-season meetings with the Panthers.
With this information, we know three of the first four games of the season for Arizona. They will start off on the road against the Saints, then play the Panthers at home in Week 2. In Week 4, they host the Seattle Seahawks for a Thursday night game.
The full schedule will come out soon.
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